Middle cerebral artery to uterine artery pulsatility index ratios in pregnancy with fetal growth restriction regarding negative perinatal outcomes

Background/Aim: Fetal growth restriction (FGR) causes a high risk of perinatal morbidity and mortality, the timing correct delivery time decision remains controversial. Cerebroplacental ratio (CPR), umbilical artery, uterine artery (UA) middle cerebral (MCA) Doppler studies are used to predict adverse outcomes in FGR. However, since there is insufficient reliability for each separately together, search new methods continues. This retrospective study was conducted determine degree neonatal fetuses suspected having FGR by evaluating MCA UA pulsatility index (PI) ratios together with frequently examinations. Methods: cohort single-center hospital approval Medical Institutional Ethics Committee. A total 424 pregnant women admitted tertiary diagnosed between July 2020 December 2021 who were informed approved included study. Gestational age confirmed first trimester sonographic measurements pregnancy. All examined USG mean UA, fetal MCA, ductus venosus, CPR (MCA/umbilical ratio) cerebrouterine (MCA/UA) PI values measured. Negative recorded as blood gas level newborn at 7.2 below, Apgar score 7 below fifth minute, needing intensive care (NICU). Adverse postnatal compared findings. If no signs negative outcome, it considered positive outcome. least one symptoms present, outcome Results: Decreased decreased significantly positively associated an increased likelihood exhibiting pregnancies (P < 0.001, P respectively). The receiver operating characteristic (ROC) curve analysis showed that optimal cut-off value 1.41 57.37% sensitivity 62.50% specificity (AUC: 0.629; 95% CI: 0.581–0.675). When taken 1.2069, 42.86% 83.93% predicting this 0.001). Conclusion: most successful criterion distinguishing outcomes. It has been demonstrated after can also be distinction. higher than artery. situation shows (alone or when evaluated PPV NPV ratios) added other examinations